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KMID : 0892920110200040189
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Experimental Neurobiology
2011 Volume.20 No. 4 p.189 ~ p.196
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Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats
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Lee Hyun-Joo
Nam Yun-Jun
Koh Chin-Su
Im Chang-Kyun
Seo In-Seok
Choi Seung-Jin
Shin Hyung-Cheul
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Abstract
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In this study, we characterize the hemodynamic changes in the main olfactory bulb of anesthetized Sprague-Dawley (SD) rats with near-infrared spectroscopy (NIRS, ISS Imagent) during presentation of two different odorants. Odorants were presented for 10 seconds with clean air via an automatic odor stimulator. Odorants are: (i) plain air as a reference (Blank), (ii) 2-Heptanone (HEP), (iii) Isopropylbenzene (IB). Our results indicated that a plain air did not cause any change in the concentrations of oxygenated (Δ[HbO2]) and deoxygenated hemoglobin (Δ[Hbr]), but HEP and IB induced strong changes. Furthermore, these odor-specific changes had regional differences within the MOB. Our results suggest that NIRS technology might be a useful tool to identify of various odorants in a non-invasive manner using animals which has a superb olfactory system.
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KEYWORD
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near-infrared spectroscopy (NIRS), hemodynamic response, main olfactory bulb (MOB), non-invasive, odorant, brain-machine interface (BMI)
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